12" x 12" = 1 square foot, so you need 452 of them.
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If you mean 12" x 12" (= 1 ft²) then you will need 224 pavers.
72
144 Assuming paver is 12x12 INCHES and patio is 12x12 FEET One paver in corner to start needs 12 of them for one row 12 feet along; then same upwards. So 12 times 12 pavers = 144 total.
272 Get 300 to be safe.
362. Get 400 to be safe.