If you mean 16 ft x 16 ft then 2 tiles will suffice. If you did not mean 16 ft x 16 ft you could have considered mentioning what units of measurement you meant.
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297 16x16-inch tiles.
Assuming you mean 16x16 inches tiles... 441 tiles would cover the area exactly
141
125 16-inch tiles.
Two tiles of 16 ft*16 ft will cover 512 square feet.