If the order of the five in the set makes a difference, there are (25 x 24 x 23 x 22 x 21) = 6,375,600 sets.
If the order doesn't matter, then there are (25 x 24 x 23 x 22 x 21) / (5 x 4 x 3 x 2 x 1) = 53,130 sets.
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By making a number tree that could have as many as 1,000,000 combos.
Could you generate a complete set of 6 number combinations from 45 numbers ?
There are 5*5*5 = 125 such numbers.
86,450
375