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It is not clear whether the strength of the solution is given in terms of mass/mass or volume/volume (or mass/volume). Without that information, it is not possile to answer the question.

Depending on which one you may need the density of the active ingredient or of the solvent to convert between mass and volume of that component.

Q: How many milligrams of an active ingredient are needed to make 400 ml of a 1 in 1000 solution?

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You need 256 litres.

50liters

4.84

A formula is a statement. It's not a problem or an exercise to which a solution is needed.

50 Liters of the 60% solution.

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