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In 2009, about 32% of car crashes involve alcohol, which is a legally available drug. That would be around 11,000 deaths.
Other drug impairment data is much harder to come by due to the difficulty in testing for those chemicals in the body. One would not be wrong if the estimate would be between 40 to 50% of deaths related to one or more drivers involved in a fatal crash might be impaired by alcohol, antihistamines, marijuana, barbiturates, depressants, etc. Estimates range from 14,000 to 16,000 deaths per year. It might even be higher.
This is according to research conducted by the US DOT, National Accident Sampling System.
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