(4 + 3 + 1) x 2 = 16
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2 * 2 * 2 * 2 It's not possible to make 16 without using the same numbers twice or without using whole numbers.
3-1=2 then 2x2x4=16.
1 x 16 = 16 2 x 8 = 16 4 x 4 = 16 8 x 2 = 16 16 x 1 = 16
(1+3+4) * 2 = 16
3-1=2 2x2=4 4x4=16 or 3-1=2 2*4=8 8*2=16