No. Whole numbers are counting numbers and zero.
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6 is a whole number -47.03 is a negative number -179 is a negative whole number
Different whole numbers are always whole numbers, but I suspect you meant to ask about the difference between whole numbers. You can subtract two whole numbers and get a negative result. Whole numbers can't be negative.
Actually the set of integers is the same as the set of whole numbers since the whole numbers include negative whole numbers and zero.
Integers
They can be. For example, -3 is a negative whole number.