Just 211.
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-200, -20, -10 and 10
220
The factorizations of both numbers use 2 and 5, and each has only two other factors (for 220, 2 and 11 - for 390, 3 and 13, which represent the primes immediately following the ones for 220).
Yes; they are 51, 53, 57, 59.
100 + 50 - 200 - 220 = -270