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There is no answer to a manipulated variable because "a manipulated variable" is not a question!
1. Image acquisition 2. Image restoration/enhancement 3. Image segmentation 4. Image interpretation
operational definition of a manipulated variable
A pixel, or picture element, is the smallest bit of an image that can be addressed and manipulated. Its size depends on the technology being used so there is no simple answer to the question.
A manipulated variable is not changed on purpose.