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The QTc Fredericia is calculated using the formula: QTc = QT / √(RR), where QT is the measured QT interval in milliseconds and RR is the RR interval in seconds. First, convert the RR interval from milliseconds to seconds by dividing by 1000. Then, plug the QT and RR values into the formula to obtain the corrected QT interval. This adjustment accounts for heart rate variations, providing a more accurate assessment of cardiac repolarization.