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Hypofibrinogenemia affect on pt ptt results?

Patients with low levels of fibrinogen have prolonged PTT in most cases.


Why ptt is higher than pt?

PTT (partial thromboplastin time) is typically higher than PT (prothrombin time) because they measure different aspects of the clotting process. PTT assesses the intrinsic and common pathways of coagulation, while PT evaluates the extrinsic and common pathways. Conditions affecting the intrinsic pathway, such as deficiencies in factors VIII, IX, or XI, can prolong PTT without impacting PT. Additionally, PTT is more sensitive to certain anticoagulants and disorders, leading to higher values in specific clinical scenarios.


What samples need to be run 15 minutes apon drawing ptt ABG PKU?

For tests such as PTT (Partial Thromboplastin Time), ABG (Arterial Blood Gas), and PKU (Phenylketonuria), it is crucial to run the samples promptly after drawing to ensure accuracy. Specifically, ABG samples should be analyzed within 15 minutes to prevent changes in gas levels due to metabolism. Similarly, PTT samples should be processed quickly to ensure reliable coagulation results, while PKU samples should ideally be analyzed as soon as possible to maintain the stability of the metabolites being measured.


Why is it important to run a PT and PTT on any sample for a thrombophilia workup?

There are two ways (pathways) that the blood clots. One is the intrinsic and the other is the extrinsic. There are clotting factors (about 13) that are unique to both pathways. The PT measures one pathway while the PTT measures the other. There are also factors that both pathways share or have in common. By testing both the PT and PTT, you are esentially testing for all the clotting factors collectively without ruling out a specific factor which is very expensive to test. Now, these are usually performed prior to a surgery in order to let the surgeons know if there is a bleeding risk to the patient. This process doesn't include other factors that have to do with the clotting process like platelets counts, platelet aggregation tests (bleeding time), or biochemical imbalances like calcium deficiencys.