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If by "2aXaXa", you actually mean "2a3", then the derivative with respect to a is 6a2. On the other hand, if you actually mean "2a3X2", then it's derivative with respect to X would be 6a2X2(da/dx) + 4a3X. If "a" is simply a constant though, then it's derivative is 4a3X
It means that the first derivative is a constant. The derivative may be with regard to time or any other variable.
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"Derivative of"
The derivative of a curve is basically the slope of the curve. If we say, for example, that if y = 2x, the derivative is 2, that means that at any point the line has this slope. If we say that for the function y = x2, the derivative is 2x, that means that at any point "x", the slope is twice the value of "x".