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C2a
The complement is 60 degrees.
objective complement
example modifier and complement
The complement of an event occurring is that it does not occur.
Factor B is the key complement protein that helps activate the alternative pathway of complement activation. It forms a complex with Factor D and is cleaved by Factor D to produce the active fragment, which leads to further activation of the alternative pathway.
activation of the complement via the alternative pathway
C2a
Membrane cofactor protein (MCP) acts as a cofactor for Factor I, which degrades C3b and C4b proteins, thus preventing the amplification of complement activation. By accelerating the decay of C3 convertases, MCP helps regulate the complement system and protect host cells from excessive complement-mediated damage.
complement fixation and activation of the antibody
It does not rely on activation by antibodies.
neutralization of the antigen, agglutination or precipitation, and complement activation.
Complement activation can lead to direct killing of pathogens by forming pores in their cell membranes, promoting inflammation by recruiting immune cells to the site of infection, and facilitating clearance of immune complexes and cellular debris.
Complement activation is a cascade of proteins in the immune system that helps to opsonize pathogens for phagocytosis, recruit inflammatory cells, and directly lyse target cells. It can be activated through three pathways: classical, lectin, and alternative pathways, and plays a critical role in innate immunity.
IgM is more efficient in activating complement than IgG because of its larger size and pentameric structure, which allows for more binding sites and better clustering of complement proteins. This leads to a more robust activation of the complement cascade and increased inflammation and opsonization.
The specific immune response that may not occur when Staphylococcus aureus enters the bloodstream is the activation of the complement system. This response involves a series of proteins that help to eliminate invading microorganisms, but certain strains of Staphylococcus aureus possess proteins that can inhibit or evade complement activation, allowing the bacterium to evade immune detection and destruction.
Having an elevated C3 and C4 complement levels may suggest inflammation or activation of the immune system. It can be seen in conditions such as autoimmune diseases, infections, or certain cancers. Further evaluation by a healthcare provider is important to determine the underlying cause.