A positive chronotrope is something that increases the heatbeat.
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Chronotropic drugs are drugs which affect the heart rate. Positive chronotropic drugs increase heart rate, and negative chronotropic drugs decrease heart rate.
Negative * positive = negative Positive * positive = positive Negative * negative = positive
positive and a positive is a positive negative and a negative is a positive to answer your question: positive and a negative is a negative.
Negative * positive = negative Positive * positive = positive Negative * negative = positive