It is possible to find a polynomial of order 6 that will generate the above sequence of numbers and ANY seventh number. And, there are non-polynomial rules that will do the same.
The simplest polynomial is
Un = (177n5 - 3030n4 + 19475n3 - 57990n2 + 78688n - 27600)/120 for n = 1, 2, 3, ... and, according to this rule, the next number is 512.
81
-243
The next number is 243, because 81x3=243.
651 is the next number.
20
243
625
81
-243
The next number is 20.
It is 3 times 81 = 243
The next number is 243, because 81x3=243.
651 is the next number.
225
81
45 54
20