not sure, but i think it means someones lost it/gone crazy etc. i think it comes from the Indians being put in reservations and if you "go off the reservation" your crazy you could get linched or shot or something.
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it derives from a 15th Century word 'Kilter or Kelter' meaning 'good condition' Further to that origin unknown. Off kilter thus meaning not functioning properly.
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The origin is from Babylonia
what is the history and origin of mathematics
The origin of the word data is Latin ....