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It depends on what kinds of similarities and differences you are looking for. 2 is the only single digit number. 17 is the only Prime number not divisible by 2.
That being said, I think 28 is the odd-one-out. All the numbers except for 28 are 1 away from perfect squares (1, 64, 49, 16, 81, 121). As opposed to these numbers, 28 is one away from a perfect cube (27).
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Earn +20 ptsQ: What number doesn't belong 2-65-50-17-82-28-122?
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