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The highest common factor is 4
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1, 2, and 4
2 3 4 6 8 12 16 24 32 48
These do: 1, 2, 3, 4, 6, 8, 12, 16, 24, 48.
The first number that 12 and 16 go into is 48.
13 is the only prime number between 12 and 16.