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it's 12.
In all there are 12 ! ways. If Mr and Mrs S are treated as a single unit, then there are 11! ways of arranging the 10 other people with Mr and Mrs S together. But these can be Mr-Mrs or Mrs-Mr so, in fact, there are 2*11! ways in which Mr and Mrs S are together. So the number of ways in which they are NOT together is 12! - 2*11! = 399,168,000
On a calculator: 43C5 = 962598 This is for combinations and not permutations, so in essence, the order of the 5 number combinations does not matter. Yours Truly, Mr Greatness
There is no limit to the number of times that an agent can sell a house, because anyone who owns a house is free to sell that house. So Mr. Smith sells the house to Mr. Jones, who then sells the house to Mr. Arbuckle, who then sells the house to Mr. Gwillam, who then sells the house to Ms. Freund, and so forth. And everybody can use the same real estate agent if they so desire.
enter 11 change to -11 by hitting the +/- key MS (save in memory) cancel (C) enter the number you want divided / (divide by) MR (memory recall) =