Quite simply, there is no rule that states that all multiples of a one-digit number have to end with that same digit, and no reason why it should be so. In the case of 2, and simply because 10 is a multiple of 2, the last digit (of a multiple of 2) is also a multiple of 2 - but it doesn't even have to be 2; it can be 0, 2, 4, 6, 8. Similar with 5, since 10 is also a multiple of 5.
In the case of 4, since 100 is a multiple of 4, the last two digits of any multiple of 4 are a multiple of 4. For instance, take the number 4524 - since the last two digits (24) are a multiple of 4, the whole number is.
Suggestion: Take some multiples of 4 (or of some other number), and try to look for patterns.
Note that for some numbers, the patterns are so complicated, that it's easier to figure out whether a number is a multiple of another by actually doing the division.
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All of the four-digit multiples of 400 end in 00.
They all end in zero.
No, 5x2 = 10 which does not end in 5. All multiples of 5 will always end in a 5 or 0
2,4,6,8,0
NO besause 5s multiples are only numbers that end with 0 and 5s so no.....!!!