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None of the zeros in that number are significant.
Any number that is not zero is significant. However, zeros that appear between non-zeros are significant. Even more confusing is that leading zeros are not significant while trailing zeros are. So, it really depends on what you are looking at. And where the zeros are.
There is nothing that zeros are always considered. Zeros in some positions are significant, in other position are not. There is no always.
Zeros can be significant or not, depending on their position in a number. Leading zeros (those before the first non-zero digit) are not significant, while trailing zeros in a decimal number are significant. For whole numbers, trailing zeros may or may not be considered significant depending on whether a decimal point is present. It's important to follow the rules of significant figures to determine their significance in a given context.
Five - any zeros after the decimal are significant unless they're placeholders. Any zeros between significant digits are significant.