Ah, isn't that a lovely question? You see, milliliters and milligrams are like two friends holding hands. Milliliters measure volume, while milligrams measure weight. To convert, we need to know the density of the substance in question. Once we have that, we can use the formula: milliliters x density = milligrams. Just a happy little calculation to brighten your day!
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That depends what substance is in the 500 ml volume, and how much mass is in each ml of that substance.
If the 500 ml are full of stones or lead, they contain many many mg of mass.
If the 500 ml are full of water, they contain roughly 5,000 mg of mass.
If the 500 ml are full of air, they contain far fewer mg of mass.
If the 500 ml are empty, they contain no mg of mass at all.