Positive: Euphoria, decrees anxiety, pain killing, variety of intake options leading to emphasis on certain effects (ie, consuming opium orally can be better used for anxiety and smoking it can be better used for chronic pain), relaxation, creative/philosophical/ deep thinking, increase appreciation of various art forms, pleasant body feel.
Neutral: Sedation, general change in consciousness, change in vision, some experience varied levels of visual hallucinations/ distortions, tiredness/nod, stimulation, constipation (generally considered negative, but positive if you have diarrhea), respiratory depression.
Negative: addiction, withdrawals, mental fog, overdose possible, anxiety, dry mouth, histamine release (makes you itchy), possible hangover.
Source: Personal/anecdotal experience as well as research.
Add to this as you like, everyone is different.
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what is the positive and nagetive effects
negative effects
Positive effects are slight because people indulge themselves anyway. Negative effects entail emergence of organized crime and violence
Positive + Negative = Negative Negative + Negative = Positive Positive + Positive = Positive Negative + Positive = Negative
The rules for the sign (positive or negative) of the result of a multiplication is the same as division. For multiplication: Positive * Positive --> Positive Positive * Negative --> Negative Negative * Positive --> Negative Negative * Negative --> Positive For division: Positive / Positive --> Positive Positive / Negative --> Negative Negative / Positive --> Negative Negative / Negative --> Positive