243 is one possibility.
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49 equals 72, and the next square number is 82 = 64.
If you look at this series, you can see that each number is 2/3 of the one before it. The next number then is 2/3 * 32, which equals 64/3, or 21 1/3.
4.5 Each number is divided by 2 to get the next number.
The next number in the sequence is... 360.
25