If you can count from one to nine, you can line up a set of numbers from largest to smallest. Start with the largest number, which in this case is a 9. Now, which number comes next? The next largest number is 7 ... and just keep going until you get to the end.
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999
The biggest 4 digit number that can be made from using the digits of 850236, using a digit at most once, is 8653.
-4790281
Assuming each digit only once: 65432 (and no further mathematical operations).
Oh, dude, the biggest number you can make using the digits 9, 5, and 1 is 951. I mean, unless you want to get all fancy and start multiplying or something, but like, who has time for that? Just stick with 951 and call it a day.