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It's what changes when you alter the manipulated variable.

Examples:

In an experiment testing how tall anplant grows in different amounts of sunlight - the manipulated variable is the sunlight, the responding variable is the height of the plant.

In an experiment testing how much carbon dioxide produced when different amounts of baking soda react to vinegar - the manip. variable is the baking soda amount, the resp. variable is the carbon dioxide.

In an experiment testing how different vitamins affect a person - the manip. variable is the vitamin, the resp. variable is the effect on the person.

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Q: What are examples of a responding variable in a lab investigation?
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