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An F-statistic is a measure that is calculated from a sample. It is a ratio of two lots of sums of squares of Normal variates. The sampling distribution of this ratio follows the F distribution.

The F-statistic is used to test whether the variances of two samples, or a sample and population, are the same. It is also used in the analysis of variance (ANOVA) to determine what proportion of the variance can be "explained" by regression.

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