Don't know whether you're talking same units or feet and inches, but here goes anyway:
If you mean 16 x 12 inches and 4 x 8 inches then 16 x 12 needs 3 across and 2 down ie 6 tiles.
If you mean 16 x 12 feet and 4 x 8 inch tiles you will need 24 across and 36 down ie a total of 864 tiles.
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Eight squares are needed.
12*12 = 144
320
There are 9 squares I can see 12 squares in an array of 2 * 4 squares
192 of them. Get extra for breakage.