There can be. Commas are used to break up long strings of numbers and a comma or space can be used for this purpose in any base.
A word of warning, though. In some European countries, the decimal "point" is a comma and the thousand separator is a point. The role of the comma and the point are swapped around.
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45,000- the forty five part is the numbers before the comma. This is a comma , the thousand part means three zeros after the comma.
-3
Five.Five.Five.Five.
Five thousand and thirty in numbers is 5,030. The comma is optional.
The symbols used are the numbers 0 to 4. Five is represented by 10, Twenty-five is represented by 100 and Sixty is represented by 220. For more info on the Quinary system (base 5) check the wiki reference below.