Mode of action of Telmisartan

Updated: 11/3/2022
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mod of acetion o telmisartan

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Q: Mode of action of Telmisartan
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Why olmesartan is better than telmisartan?

is Losarten a subsitute for telmisartan

Is telmisartan an alpha blocker?

No, Telmisartan is not an alpha blocker, it is a receptor blocker.

What are the pharmacological advantages of telmisartan over valsartan?

telmisartan lowered both systolic and diastolic BP to a greater extent than did valsartan

What is the intrrnational brand of telmisartan?

Telma in India

How olmesartan superior than telmisartan?

Olmesartan have higher binding affinity to AT1 receptor. As the molecule has lighter group, the dissociation with AT1 receptor is significantly lower when compared to Telmisartan.

What is the difference between olmesartan and telmisartan?

Telmisartan has proven mortality benefits in patients at high risk of cardiovascular events, regardless of blood pressure drops (see ONTARGET trial)Telmisartan and olmesartan are indicated for use in patients with hypertension, and telmisartan has an additional indication for the prevention of cardiovascular morbidity and mortality in patients over 55 years with- coronary artery disease- peripheral artery disease- previous stroke- previous TIA- high risk diabetes with evidence of end-organ damage, such as renal (see approved TGA indications)Olmesartan does not have any additional indications.Telmisartan has sustained blood pressure lowering effects, which last for up to 48 hours (see Product Information)Telmisartan has a longer half-life than olmesartan (see Product Information)Telmisartan has the lowest renal clearance, olmesartan is contraindicated in patients with severe renal impairment (see Product Information)ROADMAP Study with olmesartan raised concerns of increased myocardial infarcts, theorised to be due to the quick onset of action (see ROADMAP trial)

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