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Limitations of Standard Costing # It cannot be used in those organizations where non-standard products are produced. If the production is undertaken according to the customer specifications, then each job will involve different amount of expenditures. # The process of setting standard is a difficult task, as it requires technical skills. The time and motion study is required to be undertaken for this purpose. These studies require a lot of time and money. # There are no inset circumstances to be considered for fixing standards. The conditions under which standards are fixed do not remain static. With the change in circumstances, if the standards are not revised the same become impracticable. # The fixing of responsibility is not an easy task. The variances are to be classified into controllable and uncontrollable variances. Standard costing is applicable only for controllable variances. For instance, if the industry changed the technology then the system will not be suitable. In that case, we will have to change or revise the standards. A frequent revision of standards will become costly.
Only two thirds
Single ascending dose study: a small group of subjects receive single dose of the investigated drug; the dosage is escalated for a new group of subjects only when certain safety criteria are met after a period of observation time Multiple asceding dose study: a group of subject receive multiple dosing of the investigated drug and a number of PK/PD parameters are observed. Later the dosage is escalated for another new group of subjects for multiple dosing, until a predefined dose level.
Only if there are more than 2 objects in the series.
temperature