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Mode of action of Rabeprazole?
Rabeprazole is a selective and irreversible proton pump inhibitor. Rabeprazole suppresses gastric acid secretion by specific inhibition of the hydrogen-potassium adenosine triphosphatase (H+, K+-ATPase) enzyme system found at the secretory surface of parietal cells. It inhibits the final transport of hydrogen ions (via exchange with potassium ions) into the gastric lumen. Since the H+, K +-ATPase enzyme system is regarded as the acid (proton) pump of the gastric mucosa, rabeprazole is known as a gastric acid pump inhibitor. Rabeprazole does not have anticholinergic or histamine H2-receptor antagonist properties
What is the functions of pepsiniogen?
Pepsinogen reacts with the gastric juices of the stomach to form an enzyme called pepsin, which is essential to digestion.
When should cholinergic drugs be used with caution?
They should be used with caution in patients with asthma, epilepsy, slow heart beat, hyperthyroidism, or gastric ulcers.
What does Cyclooxygenase 1 do?
Cyclooxygenase 1 is important for homeostatic maintenance such as platelet aggregation, the regulation of blood flow in the kidney and stomach, and the regulation of gastric acid secretion
What is gastric segmentation?
"In this process, rings of smooth muscle in the wall repeatedly contract and relax. The result is a back-and-forth movement that mixes digested material and forces it against the wall
