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Q: What is complement opsonization?
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What is the function of the complement cascade called opsonization?

Opsonization is a process in which pathogens are marked for destruction by phagocytic cells. It involves the binding of complement proteins to the surface of the pathogen, making it easier for phagocytes to recognize and engulf the pathogen.


What is it called when some of the chemicals released during complement fixation enhance phagocytosis?

Opsonization Chemotaxis


How does opsonization occur?

Opsonization occurs when antibodies or complement proteins bind to pathogens, such as bacteria, making them more recognizable to phagocytic cells like macrophages and neutrophils. This facilitates the process of phagocytosis, where the pathogen is engulfed and destroyed by the immune cells.


Ag - Ab binding may result in?

The binding of antigen and antibody may result in the formation of immune complexes, which can activate complement system leading to inflammation and tissue damage. Additionally, it can also lead to neutralization or opsonization of the antigen, facilitating its clearance by immune cells.


Why IGM is so much efficient in activating complement than IgG?

IgM is more efficient in activating complement than IgG because of its larger size and pentameric structure, which allows for more binding sites and better clustering of complement proteins. This leads to a more robust activation of the complement cascade and increased inflammation and opsonization.


Which of the following is an effect of complement activation?

Complement activation can lead to direct killing of pathogens by forming pores in their cell membranes, promoting inflammation by recruiting immune cells to the site of infection, and facilitating clearance of immune complexes and cellular debris.


The group of proteins that normally circulate in the blood in an inactive form and are activated by contact with nonspecific antigens such as foreign blood cells or bacteria?

These proteins are part of the complement system, which forms a crucial part of the immune response. Once activated, the complement proteins can lead to the destruction of pathogens through processes such as opsonization, inflammation, and cell lysis.


What does complement proteins do?

Complement is part of the innate immune system (one you are born with). It consists of small protein molecules that circulate in the blood stream. Complement has three pathways, The classic pathway; The alternative pathway; and the lectin pathway. In the classical pathway, complement is activated by triggers such as the binding of an antigen to an antibody. In the alternative pathway, Complement is part of the natural immune system and complement assist in the opsonization, or the marking of an antigen to be destroyed by a phagocyte. This like the antigen has been marked with black marker so that a killer cell (phagocyte-cell eater) can find it to eat it. Finally the lectin pathway, which is similar to the classical pathway in terms of structure but this pathway starts with lectin or ficolin binding to sugars. After activation complement can trigger any number of events such as opsonization, chemotaxis, inflammation, and lysis (breaking) of cells.


How is opsonization associated with inflammation?

In the immune system, opsonization occurs and causes swelling, redness, production at the site of the infection and pain and discomfort.


What is The binding of complement proteins to certain sugars or proteins on a foreign Cell's surface?

Opsonization is the process where complement proteins bind to sugars or proteins on a foreign cell's surface, which marks the cell for destruction by phagocytic cells like macrophages and neutrophils. This process enhances the immune response against the foreign cell, helping to eliminate it from the body.


What are the five different types of Igs and functions?

The five different types of immunoglobulins (Igs) are IgG, IgA, IgM, IgD, and IgE. Their functions include neutralization of pathogens, opsonization for phagocytosis, activation of complement system, mucosal immunity, and mediation of allergic responses.


What is the difference between opsonization and neutralization?

Opsonization involves an antibody binding to a pathogen itself while neutralizing invovles an antibody binding to a toxin, AKA something the pathogen produces.