The equation for the slope of a line in the xy plane is change in y per unit change in x.
So, if A = (xa, ya) and B = (xb, yb) are two points on the line
then slope = (yb - ya)/(xb - xa). The slope is undefined if xb = xa. In the latter case, the line is vertical, and its slope is undefined (or infinite).
If the line is a curve then you need to take the limit of the above ratio as (xb-xa) tends to zero.
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A horizontal line has a slope of zero. The equation of a horizontal line is y = a.
It is the slope.
An equation of a line requires two parameters. The slope, by itself, is not enough.
If the equation of a line is in the form ax + by + c = 0 then the slope of the line will be -a/b.
If the equation is y=12x, the slope is 12