The same amount of units cubed as there is space to be filled. Say there is a cube with all of the side lengths being x. To calculate volume, the formula is length times width times height, so x times x times x. That equals x cubed. To fill the space, you need x cubed units.
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Volume
The capacity or volume.
Which refers to the number of cubic units inside a space figure?
Since "amount of matter" is measured as an object's mass and "a given space" is measured as volume, the amount of matter in an a given space should equal mass/volume. Mass divided by volume is an object's density. Acceptable units of density include: grams/liters, kilograms/cubic meters, slugs/cubic inch, slugs/cubic foot, and many others.
That depends on the 3rd dimension which has not been given