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4 microns is smaller. 600 messh related to openings per square inch. The thickness of screen wire must be reduced from this opening size. For example, 500 mesh screens are rated to have an average 25 microns opening size. For 600 mesh this comes to approximately 21 microns.
Mesh size is usually used in the US. It's just an alternative system used to describe the hole size. For example, 35 mesh (US) is the same as 0.5mm or 500 microns.
The answer depends on whether 100 is more or less than 500!
100 microns is 20 times thicker than 5 microns
1mm is 1000 microns