Yes, you may do that.
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If you draw one out, replace it, and draw another out, it's independent. If you draw one out, DON'T replace it, and draw another out, it's dependent. (Similarly if you draw them both out at the same time.)
No, if a draw 4 is placed, the player MUST draw 4, there is no way out of it. However if the player who placed the draw 4 has a card that is the current colour, you can challenge them, they then have to show there cards, if they do then they must draw 2, but if you are wrong you must draw 2 extra cards.
Red card- 1/2 CLUB-1/4
When the Draw 2 card is played, the next player only draws two cards; his turn is forfeited. The next player after the one who drew may play the Wild Draw 4 and declare the color, but only if he does not have a card of the same color as the Draw 2. If the next player, the potential victim of the Wild Draw 4, doesn't believe that he didn't have a card of the same color as the Draw 2, that player may challenge. At that point the one who played the Draw 4 must show his cards. If the challenger was right, the one who played the Draw 4 picks it up, plays a legal card, and draws four cards. If the challenger was wrong, he must draw two extra cards in addition to the four.
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