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This is a difficult question to answer. The pure answer is no. In reality, it depends on the level of randomness in the data. If you plot the data, it will give you an idea of the randomness. Even with 10 data points, 1 or 2 outliers can significantly change the regression equation. I am not aware of a rule of thumb on the minimum number of data points. Obviously, the more the better. Also, calculate the correlation coefficient. Be sure to follow the rules of regression. See the following website: http:/www.duke.edu/~rnau/testing.htm

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Q: Do you need more than 10 observations in linear regression?
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What is the difference between simple and multiple linear regression?

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When would you use simple linear regression?

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