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6P4 = 6!/(6-4)! = 6 * 5 * 4 * 3 = 360 four letter permutations from 6 different letters.

6C4 = 6!/[4!∙(6-4)!] = 15 four letter combinationsfrom 6 different letters.

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Q: How many different 4 letter combinations can you make with 6 different letters?
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