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It depends on whether the order of the numbers matters. For example, if 1234 and 2413 are considered to be the same combination or not. It also depends on whether the numbers can be used more than once. There is a different procedure for each case. To find out how many unique combinations there are, first lay out four blank spaces (since the combinations are 4 numbers long) with multiplication symbols between them. ______ * ______ * ______ * ______ Then, since there are 6 choices for the first spot, put a six on it. If it's okay to re-use digits, the second spot will also have a 6, as will the third and fourth spots. If it's not okay to re-use digits, the numbers would be 6*5*4*3 since the number of choices is being lowered every time one is chosen. 6*6*6*6 = 1296 unique combinations with repetition allowed

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Q: How many 4 number combinations using digits 1 2 3 4 5 6?
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How many 4 number combinations using digits 1357 one and only once?

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