The difficulties in constructing multiple choice is determined by how easy or hard a question can be. For example, If the value of a question is set at low, it means that this question is hard whereas a high value question is easy.
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Single ascending dose study: a small group of subjects receive single dose of the investigated drug; the dosage is escalated for a new group of subjects only when certain safety criteria are met after a period of observation time Multiple asceding dose study: a group of subject receive multiple dosing of the investigated drug and a number of PK/PD parameters are observed. Later the dosage is escalated for another new group of subjects for multiple dosing, until a predefined dose level.
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Did you hear about the girl and the guy who met in a revolving door and started going around together is the answer.
i mean met