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To find the 2s complement, invert all the bits (to get the 1s complement) and add 1:

10001100 00111001 → 01110011 11000110 + 1 = 01110011 11000111

If you have an operator missing between the two numbers then if it is subtract:

10001100 - 00111001 = 10001100 + 11000111 = carry set & 01010011 & overflow set.

If not subtract but some other operator, please re-ask your question with the operator written out as a word.

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Q: What is the 2's complement addition for 10001100 00111001?
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