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To calculate the number of 4-digit combinations you can get from the numbers 1, 2, 2, and 6, we need to consider that the number 2 is repeated. Therefore, the total number of combinations is calculated using the formula for permutations of a multiset, which is 4! / (2!1!1!) = 12. So, there are 12 unique 4-digit combinations that can be formed from the numbers 1, 2, 2, and 6.
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