There are 8C6 = 8*7/(2*1) = 28 combinations.
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If the numbers can be repeated and the numbers are 0-9 then there are 1000 different combinations.
The number of combinations of six numbers that can be made from seven numbers will depend on if you can repeat numbers. In all there are over 2,000 different numbers that can be made.
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362,880 1x2x3x4x5x6x7x8x9=362,880