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The slope changes as the value of x changes. For any point x, the slope is -8x.
The coefficient of x changes as the slope changes.
A single point cannot determine the slope of a straight line. It can, therefore, have any slope at all.
The angle that the line makes with the axes changes.
The slope of a curved line at a point is the slope of the tangent to the curve at that point. If you know the equation of the curve and the curve is well behaved, you can find the derivative of the equation of the curve. The value of the derivative, at the point in question, is the slope of the curved line at that point.